Gestational trophoblastic neoplasia is a rare type of neoplasia that develops from foetal trophoblastic tissues and is classified as semi-allografts. The majority of gestational trophoblastic tumours are benign hydatidiform moles. Choriocarcinoma is the malignant type of gestational trophoblastic illness. The condition is widespread in Asian and African countries, with roughly one in every 400 pregnancies in India. The major study for the diagnosis and management of GTN is the serum-HCG assay. This is crucial for detecting persistent trophoblastic illness, hence a two-year follow-up is indicated. Surgical evacuation and follow-up may be sufficient for complete and partial moles. Single-agent chemotherapy can be used to treat women with non-metastatic GTN and those with metastatic low-risk GTN. When single-agent chemotherapy is utilised, methotrexate is the medication of choice. HCG levels of more than 40,000 U/L before therapy indicate a high-risk GTN. Multi-agent chemotherapy is used to treat them. EMA-CO is the most widely utilised regimen. Following treatment, the prognosis for GTN is currently excellent, with survival rates of nearly 100% in low-risk disease and about 86 percent in high-risk disease.
Author(S) Details
Sanjivani Wanjari
Department of Obstetrics and Gynaecology, Mahatma Gandhi Institute of Health Sciences, Sewagram, Wardha. Maharashtra, India.View Book:- https://stm.bookpi.org/RDMMR-V8/article/view/4561
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